In a previous study, Henrich et al. (ISC ‘23) demonstrate how TLS handshake performance is affected not only by different Post Quantum Cryptography (PQC) Key Encapsulation Mechanisms KEMs and security levels, but also by varying physical network conditions. In particular, they show that prior to selecting a PQC scheme replacement for TLS, it is important to conduct an analysis of the anticipated network conditions for applications that require a high level of responsiveness. In this paper, we build upon the afore mentioned work and complement the previous experiments to include digital signature PQC schemes and hybrid variants, as well as various compositions of certificate chains. Moreover, an analysis is conducted on the effects of deploying real physical servers and varying the underlying network stack configuration. Our results show that incorporating PQC signature schemes does not negatively impact the overall transmission time as substantially as poor network conditions. However, operating at high security levels frequently results in delays using PQC schemes. These findings are consistent across hybrid schemes as well. We conclude that migrating TLS to PQ-only or hybrid usage can generally be undertaken with a high degree of confidence. However, considering suboptimal network conditions or the use of higher security levels, a cautious transition is recommended. In such cases, the configuration of certificate chains or increasing the TCP Congestion Window might prove beneficial.